Top 19 US AI Startups Making Waves with $100M+ Funding in 2025

US AI Startups Leading the Way in 2025

2025 has been a remarkable year for the artificial intelligence (AI) startup scene in the United States. As reported by TechCrunch, a total of 19 AI startups have successfully raised $100 million or more in funding this year. These companies are at the forefront of innovation, pushing the boundaries of what AI technology can achieve in various sectors.

Key Takeaways from the Top AI Startups:

• These 19 US AI startups have demonstrated strong growth potential and investor confidence in their business models.
• The diversity of industries represented among the top AI startups shows the broad applicability of AI technology, from healthcare and finance to transportation and cybersecurity.
• Several startups have raised “megarounds,” indicating significant interest and support from venture capitalists and other funding sources.

As we look ahead to the rest of 2025, it is exciting to see how these leading AI startups will continue to drive innovation and shape the future of technology.

One key aspect for founders of AI startups to consider is navigating the fundraising landscape effectively. For entrepreneurs seeking to secure funding for their AI ventures, platforms like NextRound.ai can provide valuable insights and connections to potential investors. NextRound.ai offers a streamlined approach to fundraising, helping founders connect with the right investors and navigate the often complex world of fundraising with ease.

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Here are all the U.S. AI companies that have raised $100 million this year:

Source: TechCrunch

April

• SandboxAQ closed a $450 million Series E round on April 4 that valued the AI model company at $5.7 billion. The round included Nvidia, Google, and Bridgewater Associates founder Ray Dalio among other investors.
• Runway, which creates AI models for media production, raised a $308 million Series D round that was announced on April 3, valuing the company at $3 billion. It was led by General Atlantic. SoftBank, Nvidia, and Fidelity also participated.

March

• AI behemoth OpenAI raised a record-breaking $40 billion funding round that valued the startup at $300 billion. This round, which closed on March 31, was led by SoftBank with participation from Thrive Capital, Microsoft, and Coatue, among others.
• On March 25, Nexthop AI, an AI infrastructure company, announced that it had raised a Series A round led by Lightspeed Venture Partners. The $110 million round also included Kleiner Perkins, Battery Ventures, and Emergent Ventures, among others.
• Cambridge Massachusetts-based Insilico Medicine raised $110 million for its generative AI-powered drug discovery platform as announced on March 13. This Series E round valued the company at $1 billion and was co-led by Value Partners and Pudong Chuangtou.
• AI infrastructure company Celestial AI raised a $250 million Series C round that valued the company at $2.5 billion. The March 11 round was led by Fidelity with participation from Tiger Global, BlackRock, and Intel CEO Lip-Bu Tan, among others.
• Lila Sciences raised a $200 million seed round as it looks to create a science superintelligence platform. The round was led by Flagship Pioneering. The Cambridge, Massachusetts-based company also received funding from March Capital, General Catalyst, and ARK Venture Fund, among others.
• Brooklyn-based Reflection.Ai, which looks to build superintelligent autonomous systems, raised a $130 million Series A round that values the 1-year-old company at $580 million. The round was led by Lightspeed Venture Partners and CRV.
• AI coding startup Turing closed a Series E round on March 7 that valued the startup, which partners with LLM companies, at $2.2 billion. The $111 million round was led by Khazanah Nasional with participation from WestBridge Capital, Gaingels, and Sozo Ventures, among others.
• Shield AI, an AI defense tech startup, raised $240 million in a Series F round that closed on March 6. This round was co-led by L3Harris Technologies and Hanwha Aerospace, with participation from Andreessen Horowitz and the US Innovative Technology Fund, among others. The round valued the company at $5.3 billion
• AI research and large language model company Anthropic raised $3.5 billion in a Series E round that valued the startup at $61.5 billion. The round was announced on March 3 and was led by Lightspeed with participation from Salesforce Ventures, Menlo Ventures, and General Catalyst, among others.

February

• Together AI, which creates open source generative AI and AI model development infrastructure, raised a $305 million Series B round that valued the company at $3.3 billion. The February 20 round was co-led by Prosperity7 and General Catalyst with participation from Salesforce Ventures, Nvidia, Lux Capital, and others.
• AI infrastructure company Lambda raised a $480 million Series D round that was announced on February 19. The round valued the startup at nearly $2.5 billion and was co-led by SGW and Andra Capital. Nvidia, G Squared, ARK Invest, and others also participated.
• Abridge, an AI platform that transcribes patient-clinician conversations, was valued at $2.75 billion in a Series D round that was announced on February 17. The $250 million round was co-led by IVP and Elad Gil. Lightspeed, Redpoint, and Spark Capital also participated, among others.
• Eudia, an AI legal tech company, raised $105 million in a Series A round led by General Catalyst. Floodgate, Defy Ventures, and Everywhere Ventures also participated in the round in addition to other VC firms and numerous angel investors. The round closed on February 13.
• AI hardware startup EnCharge AI raised a $100 million Series B round that also closed on February 13. The round was led by Tiger Global with participation from Scout Ventures, Samsung Ventures, and RTX Ventures, among others. The Santa Clara-based business was founded in 2022.
• AI legal tech company Harvey raised a $300 million Series D round that valued the 3-year-old company at $3 billion. The round was led by Sequoia and announced on February 12. OpenAI Startup Fund, Kleiner Perkins, Elad Gil, and others also participated in the raise.

January

• Synthetic voice startup ElevenLabs raised a $180 million Series C round that valued the company at more than $3 billion. It was announced on January 30. The round was co-led by ICONIQ Growth and Andreessen Horowitz. Sequoia, NEA, Salesforce Ventures, and others also participated in the round.
• Hippocratic AI, which develops large language models for the healthcare industry, announced a $141 million Series B round on January 9. This round valued the company at more than $1.6 billion and was led by Kleiner Perkins. Andreessen Horowitz, Nvidia, and General Catalyst also participated, among others.